2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party

@ article { a92855b56bf943489b01bdd31d50a8d8, claim = “ 2021 Update on MRD in acute myeloid leukemia : a consensus document from the european LeukemiaNet MRD Working Party ”, abstract = “ measurable residual disease ( MRD ) is an important biomarker in acute myeloid leukemia ( AML ) that is used for omen, predictive, monitoring, and efficacy-response assessments. The european LeukemiaNet ( ELN ) MRD Working Party evaluated standardization and harmonization of MRD in an ongoing manner and has updated the 2018 ELN MRD recommendations based on significant developments in the discipline. New and revised recommendations were established during in-person and on-line meetings, and a 2-stage Delphi poll was conducted to optimize consensus. All recommendations are graded by levels of evidence and agreement. major changes include technical specifications for next-generation sequencing-based MRD testing and consolidative assessments of MRD regardless of engineering. early topics include manipulation of MRD as a predictive and surrogate end point for drug test ; survival of the proficiency, material, and allow time points for MRD assessment ; and clinical implications of MRD assessment. In addition to technical recommendations for flow- and molecular-MRD analysis, we provide MRD thresholds and define MRD response, and detail how machine readable dictionary results should be reported and combined if several techniques are used. MRD assessment in AML is complex and clinically relevant, and standardized approaches to application, interpretation, technical conduct, and reporting are of critical importance. “, generator = “ Michael Heuser and Freeman, { Sylvie D. } and Ossenkoppele, { Gert J. } and Francesco Buccisano and Hourigan, { Christopher S. } and Ngai, { Lok Lam } and Tettero, { Jesse M. } and Costa Bachas and Constance Baer and B { \’e } n { \’e }, { Marie Christine } and Veit B { \ ” u } cklein and Anna Czyz and Barbara Denys and Richard Dillon and Michaela Feuring-Buske and Guzman, { Monica L. } and Torsten Haferlach and Lina Han and Herzig, { Julia K. } and Jorgensen, { Jeffrey L. } and Wolfgang Kern and Konopleva, { Marina Y. } and Francis Lacombe and Marta Libura and Agata Majchrzak and Luca Maurillo and Yishai Ofran and Jan Philippe and Adriana Plesa and Claude Preudhomme and Farhad Ravandi and Christophe Roumier and Marion Subklewe and Felicitas Thol and { van de Loosdrecht }, { Arjan A. } and { van five hundred Reijden }, { Bert A. } and Adriano Venditti and Agnieszka Wierzbowska and Valk, { Peter J.M. } and Wood, { Brent L. } and Walter, { Roland B. } and christian Thiede and Konstanze D { \ ” o } hner and Roboz, { Gail J. } and Jacqueline Cloos ”,

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Reading: 2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party

bill = “ Funding information : Conflict-of-interest disclosure : M.H. serves an advisory role for Abbvie, BMS/Celgene, Daiichi Sankyo, Jazz Pharmaceuticals, Novartis, Pfizer, Roche, Tolremo ; has received honoraria from Jazz Pharmaceuticals, Janssen, and Novartis ; and has received research fund to his institution from Astellas, Bayer Pharma AG, BergenBio, Daiichi Sankyo, Jazz Pharmaceuticals, Karyopharm, Novartis, Pfizer, and Roche. S.D.F. is a Speaker Bureau member for Pfizer and Jazz Phamaceuticals. G.J.O. serves an advisory role for Novartis, Pfizer, BMS, Janssen, Celgene, AGIOS, Amgen, Gilead, Astellas, Roche, Jazz Pharmaceuticals, and Merus ; serves as a adviser for Janssen, Celgene, and Roche ; and receives research corroborate to his establish from Novartis, Janssen, and Celgene. F.B. serves an advisory function and is a Speaker Bureau member for Novartis. C.S.H. receives research confirm for his institution from Sellas. C. Baer is employed by the MML Munich Leukemia Laboratory. V.B. serves an advisory function for Amgen, Gilead, and Pfizer, and has received research fund to his mental hospital from Gilead, Celgene, and Novartis. R.D. serves an advisory function for Abbvie, Jazz Pharmacueticals, Menarini, Novartis, and Pfizer ; receives inquiry support to his initiation from Abbvie, Amgen ; is a adviser for Abbvie, Astellas, Jazz Pharmaceuticals, Pfizer ; and is a Speaker Bureau extremity for Astellas, Jazz Pharmaceuticals, Novartis, and Pfizer. M.L.G. serves an advisory function for BridgeMedicines, SeqRx, and Epsilen Bio ; and receives research fund from Cellectis, BridgeMedicines, and Daiichi Sankyo. T.H. is separate owner of the MML Munich Leukemia Laboratory. W.K. is character owner of the MML Munich Leukemia Laboratory. M.Y.K. has received research grants to her institution from AbbVie, F. Hoffman La-Roche, Stemline Therapeutics, Forty-Seven, Eli Lilly, Cellectis, Calithera, Ablynx, Agios, Ascentage, Astra Zeneca, Reata Pharmaceutical, Rafael Pharmaceutical, Sanofi, Janssen, and Genentech ; has received royalties paid to Reata Pharm ; and has a patent licensed to Eli Lilly and one pending to Novartis. M.L. is a Speaker Bureau member at Novartis and Angelini. L.M. serves an advisory character for Abbvie, Janssen, Novartis, and BMS/Celgene. Y.O. serves an advisory function for Amgen, Pfizer, Abbvie, BMS, Astellas, and Janssen ; and has received honoria from Abbvie, Novartis, Roche, Astellas, and Janssen. C.P. has received personal fees and travel/accommodations from Amgen, Janssen, Novartis, Bristol Meyer Scribb, Abbvie, and Astellas ; has received grants, personal fees, and travel/accommodations from Celgene ; has received grants from Merck ; and has received travel and hotel accommodations from Innate Pharma, Ariad, and Daiichi Sakyo. F.R. has received research fund from BMS/Celgene, Amgen, Xencor, Syros, Taiho, Astex, Prelude, Biomea Fusion, Macrogenics, Hutchmed, and Abbvie ; served as an adviser or received honoraria from BMS/Celgene, Novartis, Syros, Taiho, Jazz Pharmaceuticals, AstraZeneca, Agios, Abbvie, Amgen, and Xencor. M.S. serves an advisory function for Amgen, Celgene, Gilead, Janssen, Novartis, Pfizer, and Seattle Genetics ; received research fund to her institution from Amgen, Gilead, Miltenyi Biotec, Morphosys, Roche, and Seattle Genetics ; provided consultancy for Amgen, BMS, Celgene, Gilead, Pfizer, Novartis, and Roche ; and is a Speaker Bureau member at Amgen, Celgene, Gilead, Janssen, and Pfizer. F.T. serves an advisory role for BMS/Celgene, Novartis, Abbvie Daichi, Astellas, and Pfizer, and has received research documentation for her mental hospital from BMS/Cellgene and Novartis. A.A.v.d.L. serves an advisory function for BMS/Celgene, Amgen, Novartis, and Takeda, and has received research fund to his establish from Alexion. A.V. serves an advisory function for Novartis, Pfizer, Jazz Pharmaceuticals, Amgen, Abbvie, Gilead, Astellas, Incyte, and Janssen & Cylag ; has received research fund to the Department of Biomedicine and Prevention, University Tor Vergata from Sandoz and Jazz Pharmaceuticals ; and is a Speaker Bureau member for Pfizer. A.W. serves an advisory character for Amgen, Pfizer, Abbvie, BMS, Astellas, and Janssen ; and has received honoria from Abbvie, Novartis, Roche, Astellas, and Janssen. B.L.W. has received honoraria from Amgen, Seattle Genetics, Abbvie, Janssen, Astellas Pharma, Roche Diagnostics, and Beckman Coulter ; has served an advisory role for Sysmex ; and has received a research grants to his institute from Novartis, Amgen, Seattle Genetics, Pfizer, Juno Therapeutics, BiolineRx, Biosight, Stemline Therapeutics, Janssen Oncology, Kite, a Gilead company, and Macrogenics. R.B.W. has received inquiry grants to his institute from Agios, Amgen, Aptevo, Arog, BioLineRx, Celgene, ImmunoGen, Janssen, Jazz, Kura, MacroGenics, Pfizer, Selvita, and Stemline ; has possession interests in Amphivena ; and serves an advisory function for Agios, Amgen, Amphivena, Aptevo, Astellas, BioLineRx, Boston Biomedical, Bristol Myers Squibb, Celgene, Genentech, GlaxoSmithKline, Janssen, Jazz, Kite, Kronos, MacroGenics, New Link Genetics, Pfizer, and Race. C.T. serves an advisory function for Jazz Pharmaceuticals, Novartis ; has received honoraria from Jazz Pharmaceuticals, Janssen, Novartis, Astellas, Illumina, and Thermo Fisher Scientific ; has received inquiry support to his mental hospital from Novartis, Jazz Pharmaceuticals ; and has possession in AgenDix. K.D. serves an advisory function for Abbvie, BMS/Celgene, Daiichi Sankyo, Jazz Pharmaceuticals, Janssen, Novartis, and Roche ; has received honoraria from BMS/Celgene, Daiichi Sankyo, Jazz Pharmaceuticals, Janssen, Novartis, and Roche ; and has received research fund to her institution from Astellas, Agios, and Novartis. G.J.R. serves an advisory function for AbbVie, Actinium, Agios, Amgen, Astex, Astellas, AstraZeneca, Bayer, bluebird bio, Blueprint Medicines, Bristol Myers Squibb, Celgene, Daiichi Sankyo, Glaxo SmithKline, Helsinn, Janssen, Jasper Therapeutics, Jazz Pharmaceuticals, and MEI Pharma ; is the Independent Data Monitoring Committee ( IDMC ) Chair for Mesoblast, Novartis, Otsuka, Pfizer, Roche/Genentech, and Sandoz ; is the Independent Review Committee ( IRC ) Chair for Takeda ; and has received a research grants for her establish from Cellectis and Janssen. J.C. serves an advisory function for Novartis ; has received inquiry grants for her mental hospital from Novartis, Merus, Takeda, Genentech, and BD Biosciences ; and has received a royalty/license from Navigate and BD Biosciences. The remaining authors declare no competing fiscal interests. Funding information : This work was supported, in separate, by the Intramural Research Program, National Heart, Lung, and Blood Institute National Institutes of Health. Funding information : The authors thank Ruediger Hehlmann for continuous generous support of the ELN AML MRD Working Party on behalf of the european LeukemiaNet. This work was supported, in contribution, by the Intramural Research Program, National Heart, Lung, and Blood Institute National Institutes of Health. publisher Copyright : { \textcopyright } 2021 american Society of Hematology ”, year = “ 2021 ”, month = declination, day = “ 30 ”, department of the interior = “ 10.1182/blood.2021013626 ”,

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language = “ english ”, bulk = “ 138 ”, pages = “ 2753 — 2767 ”, diary = “ Blood ”, issn = “ 0006-4971 ”,

publisher = “ American Society of Hematology ”, number = “ 26 ”, }

source : https://shayski.com
Category : Uncategorized

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